Exploring the role of NMDA receptor in memory

Authors

  • Pooja Tiwary Poona College of Pharmacy, Bharati Vidyapeeth University, https://orcid.org/0000-0001-6486-5730
  • Krishil Oswal Poona College of Pharmacy, Bharati Vidyapeeth University,
  • Chinmay Malvankar Poona College of Pharmacy, Bharati Vidyapeeth University, https://orcid.org/0000-0001-5698-5740
  • Dileep Kumar 1Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune Maharashtra, India. 2Department of Entomology, University of California, UC Davis Comprehensive Cancer Center, Davis, One Shields Ave, Davis, CA 95616, USA.

DOI:

https://doi.org/10.5530/gjpb.2023.2.5

Keywords:

Receptor, ion channels, ligand, memory specific, neurons

Abstract

N-Methyl-D-aspartate (NMDA), a receptor belonging to the family of ionotropic glutamate receptors (iGluRs), plays various physiological and pathological roles in the central nervous system (CNS). Various other receptors located in the midbrain, such as NMDAR2B (NR2B), contribute to fear memory rather than spatial memory. Furthermore, NMDA-receptor channels produce calcium entry, essential for LTP induction; they also produce voltage-dependent excitatory postsynaptic potentials (EPSPs). Protein kinase C (PKC) activation is involved in the long-term physiological processes of LTP. This review aimed to determine the pharmacological properties of NMDA in front of native neurons.

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CITATION
DOI: 10.5530/gjpb.2023.2.5
Published: 2023-07-27

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Published

2023-07-27

How to Cite

Tiwary, P. ., Oswal, K. ., Malvankar, C. ., & Kumar, D. (2023). Exploring the role of NMDA receptor in memory. German Journal of Pharmaceuticals and Biomaterials, 2(2), 6–19. https://doi.org/10.5530/gjpb.2023.2.5

Issue

Vol. 2 No. 2 (2023): German Journal of Pharmaceuticals and Biomaterials

Section

Review Article

License

Copyright (c) 2023 Pooja Tiwary, Krishil Oswal, Chinmay Malvankar, Dileep Kumar

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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