Silver Complexes as Anticancer Agents: A Perspective Review

Authors

  • Senthil Kumar Raju Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Namakkal Dt., Tamilnadu, India https://orcid.org/0000-0003-1309-3886
  • Anandakumar Karunakaran Department of Pharmaceutical Analysis, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India https://orcid.org/0000-0002-9309-9286
  • Shridharshini Kumar Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Tiruchengode , Tamilnadu, India. https://orcid.org/0000-0002-2135-257X
  • Praveen Sekar Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India. https://orcid.org/0000-0002-3509-5981
  • Maruthamuthu Murugesan Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India. https://orcid.org/0000-0002-7797-0473
  • Mohanapriya Karthikeyan Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India.

DOI:

https://doi.org/10.5530/gjpb.2022.1.3

Keywords:

Silver complex, Anticancer, Chemotherapy, Cytotoxicity, Ligands

Abstract

Metal complexes gained more attention in the medical field, particularly cancer treatment, due to their enhanced potential and redox ability. These complexes exhibited more significant antiproliferation potential by triggering the generation of reactive oxygen species (ROS), altering cell membrane, changing cell redox potential and by DNA replication inhibition. Platinum-based metal complex Cisplatin was prepared. It was widely used in treating lung, breast, ovarian and testicular cancers; however, these complexes showed many adverse effects such as renal insufficiency and electrolyte abnormalities, neurotoxicity, ototoxicity, nausea, vomiting and drug resistance. To overcome these side effects and drug resistance mechanisms, silver metal is highly employed as a cytotoxic agent by DNA binding through the formation of disulphide bonds. Moreover, silver complexes exhibited more significant cytotoxicity with the lowest toxicity. This review highlighted silver complexes' anticancer and cytotoxic potential with various bioactive ligands.

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Structure of Silver-5-Fluorouracil Complex (25) and Silver-Naproxen Complex (26)
CITATION
DOI: 10.5530/gjpb.2022.1.3
Published: 2022-04-25

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Published

2022-04-25

How to Cite

Raju, S. K., Karunakaran, A. ., Kumar, S., Sekar, P., Murugesan, M., & Karthikeyan, M. (2022). Silver Complexes as Anticancer Agents: A Perspective Review. German Journal of Pharmaceuticals and Biomaterials, 1(1), 6–28. https://doi.org/10.5530/gjpb.2022.1.3